The Autonomic Nervous System and Heart Failure
نویسندگان
چکیده
منابع مشابه
The autonomic nervous system and heart failure.
The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities that result in neurohormonal activation and autonomic imbalance with increase in sympathetic activity and withdrawal of vagal activity. Alterations in receptor activation from this autonomic imbalance may have profound effects on cardiac function and structure. Inhibition of the sympathetic drive to the hear...
متن کاملThe sympathetic nervous system and heart failure.
Heart failure (HF) is a syndrome characterized by upregulation of the sympathetic nervous system and abnormal responsiveness of the parasympathetic nervous system. Studies in the 1980s and 1990s demonstrated that inhibition of the renin-angiotensin-aldosterone system with angiotensin-converting enzyme inhibitors improved symptoms and mortality in HF resulting from systolic dysfunction, thus pro...
متن کاملContribution of fibrosis and the autonomic nervous system to atrial fibrillation electrograms in heart failure.
BACKGROUND Fibrotic and autonomic remodeling in heart failure (HF) increase vulnerability to atrial fibrillation (AF). Because AF electrograms (EGMs) are thought to reflect the underlying structural substrate, we sought to (1) determine the differences in AF EGMs in normal versus HF atria and (2) assess how fibrosis and nerve-rich fat contribute to AF EGM characteristics in HF. METHODS AND RE...
متن کاملThe "unsympathetic" nervous system of heart failure.
Sympathetic activation in heart failure is intimately linked to disease progression and to adverse outcome.1–3 Contemporary management of heart failure relies on three antiadrenergic strategies, predicated on the hypothesis that interventions that counter sympathetic overactivity will improve both symptoms and prognosis. First, excessive central sympathetic outflow to the heart and periphery ca...
متن کاملThe Autonomic Nervous System
T sweating sunbather lying quietly in the summer sun or the racing heart and “hair-standing-on-end” sensations experienced by a person suddenly frightened by a horror movie are familiar examples of the body responding automatically to changes in the physical or emotional environment. These responses occur as a result of the actions of the autonomic portion of the nervous system and take place w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2014
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.114.302589